盖布丽（安琪拉·琼斯 Angela Jones 饰）的童年里有一段非常可怕的经历，年幼的她曾经在凶杀现场亲眼目睹死尸。这一段奇异的人生经历让盖布丽开始对尸体和死亡产生了好奇之心，这股子好奇随着她年龄的增大越发强烈起来，盖布丽甚至会特意的收藏报纸上的谋杀新闻做成剪报册，时时翻阅温习。 迈阿密接连发生凶杀案，被害者均是养尊处优的阔太太，而且无不身首异处。这起连环杀人案件很快就吸引了盖布丽的注意，为了能够更加接近命案现场，盖布丽来到了一间专门清理命案现场的保洁公司应聘成为了员工，并且在机缘巧合之下同连环杀人犯（威廉·鲍德温 William Baldwin 饰）有了一面之缘。
大璞（吴越饰）自幼跟随师傅三清子真人（午马饰）在深山学法，习得一身降妖伏魔法术。因此遭同门师兄弟嫉妒，被师傅逐出师门。 大璞驱鬼之中，识得半人半狐的长亭（何美钿饰），并与风流鬼云大少结为生死之交。在风流鬼云大少的帮助下大璞、长亭深深相爱，并喜结良缘。狐老闻讯震怒，亲自下山捉拿长亭，大璞法刀不敌身受重伤。狐老施法烧了大璞的家，并将长亭捉回等待狐仙大帝迎娶。 长亭大璞会同风流鬼云大少，并请师傅三清子出山。展开了一场人、鬼、狐三界大战……
ISSAC is an intense psychological thriller which constantly treads the lines of reality and fiction. Issac, A young reclusive mortician who inherited his stepfather's mortuary business meets a friendly waitress, Cassi. The two create an instant connection and after a night of terror, they pursue a revenge murder together. This film mixes a realistic story with surreal imagery, showing how one in isolation may operate due to the circumstances he has been given. Issac inevitably makes a choice and never questions the morality of his decisions.
