一切都由一本科幻小说引起。小说家杨匡（刘兆铭 饰）的科幻小说里描述了一种改造新人类的方法，那就是抽取人类的脑细胞，加以改造，以此甚至能控制被改造者的思想。这一切看似荒诞的想法，竟被一个阴谋控制全世界的富商看中。他出资建立了实验室，招募了一批手下，将杨匡捉了去做实验。后来，杨匡逃了出来，被人送到医院。医生原振侠（黎明 饰）武功高强，为人正义，他发现杨匡十分沉默寡言，目光呆滞，经常用水清洗双手。杨匡的反常的表现引起了原振侠的注意，他和护士彩云（朱茵 饰）决心找出杨匡背后隐藏的秘密。
在19世纪的奥地利，热情叛逆的西西与皇帝弗朗兹·约瑟夫坠入爱河，同时还要应对维也纳宫廷的胁迫、阴谋和权力斗争。
捉襟见肘的安东在一家高档宠物店找了份工作，从医治乡村农场动物的医生变成了兜售高级宠物狗零食的店员。
新一季将延续第二季的故事，自Rachel Carey（荷丽黛·格兰杰 饰）在全国直播中揭露一段伪造的政府部长视频、暴露情报机构秘密操作项目“修正”以来，已过去一年。在对“修正”计划非法使用的调查期间，Carey成为SO15反恐指挥部的代理负责人，试图通过全新的“真相行动”摄像系统重建公众对监控技术的信任。然而，一场精心策划、极其残忍的恐怖袭击突然爆发，直击英国权力核心，仅留下一位目击者。随着Carey深入调查，她被卷入一场不断扩大的地缘政治危机之中，这场危机渗透至英国政坛、安全机构乃至媒体界。一场巨大的阴谋正悄然展开，但幕后黑手究竟是谁？
Season 5 finds Murder, She Wrote's intrepid Jessica Fletcher in fine sleuthing form, and venturing farther afield from Cabot Cove--a good thing, since at the rate the murders have been happening, that town would be nearly cleaned out. Some of the best episodes take place in more exotic locales like New York (dead man on the street, wearing just one shoe), Montana (a publishing convention gone horribly wrong) and West Virginia (two whistle-blowers at a coal company found gruesomely murdered). Angela Lansbury sparkles with determination and bonhomie, hitting her stride and then some. Jessica's own life backstory is even filled out tantalizingly, especially in the episode "The Last Flight of the Dixie Damsel," in which an investigation is launched into a mysterious cargo plane that is linked, she learns to her horror, to her late husband. The series' other delight is watching for cameos by stars of a certain age, and this season doesn't disappoint, with appearances by Roddy McDowall, Shelley Fabares, and Dinah Shore--but also some up-and-comers like Megan Mullally (proof positive that the Will & Grace whine was a put-on) and future satirist Bill Maher.
Prime Video续订《大卫王朝》第二季，第一季编导将回归。
