本季描绘重返医院的牧野医生与升入初中的学生们的新篇章。藤野一希难以适应中学生活，父亲突然带回新母亲与妹妹更令其家庭归属感崩塌；而顺利完成心脏病手术的冴岛直明升入新年级，虽立志成为牧野医生般的医者，内心仍怀不安。此时，一名因病复发失去求生意志的少女出现在牧野面前。除原作剧情外，本季将新增原创角色故事线。
Tammy Fenton is an ex-special forces operative who discovers her daughter has been abducted by a ruthless human trafficking ring. She launches “hunt mode,” an all-out mission to bring her home. Aided by a former military comrade, Fenton navigates the criminal underworld, unearthing a web of corruption extending from the streets of Los Angeles to high-powered officials.
